Multiple 2D self organising map network for surface reconstruction of 3D unstructured data

Surface reconstruction is a challenging task in reverse engineering because it must represent the surface which is similar to the original object based on the data obtained. The data obtained are mostly in unstructured type whereby there is not enough information and incorrect surface will be obtained. Therefore, the data should be reorganised by finding the correct topology with minimum surface error. Previous studies showed that Self Organising Map (SOM) model, the conventional surface approximation approach with Non Uniform Rational B-Splines (NURBS) surfaces, and optimisation methods such as Genetic Algorithm (GA), Differential Evolution (DE) and Particle Swarm Optimisation (PSO) methods are widely implemented in solving the surface reconstruction. However, the model, approach and optimisation methods are still suffer from the unstructured data and accuracy problems. Therefore, the aims of this research are to propose Cube SOM (CSOM) model with multiple 2D SOM network in organising the unstructured surface data, and to propose optimised surface approximation approach in generating the NURBS surfaces. GA, DE and PSO methods are implemented to minimise the surface error by adjusting the NURBS control points. In order to test and validate the proposed model and approach, four primitive objects data and one medical image data are used. As to evaluate the performance of the proposed model and approach, three performance measurements have been used: Average Quantisation Error (AQE) and Number Of Vertices (NOV) for the CSOM model while surface error for the proposed optimised surface approximation approach. The accuracy of AQE for CSOM model has been improved to 64% and 66% when compared to 2D and 3D SOM respectively. The NOV for CSOM model has been reduced from 8000 to 2168 as compared to 3D SOM. The accuracy of surface error for the optimised surface approximation approach has been improved to 7% compared to the conventional approach. The proposed CSOM model and optimised surface approximation approach have successfully reconstructed surface of all five data with better performance based on three performance measurements used in the evaluation

The Impact of Service Quality Dimensions Towards Customers' Satisfaction in Tuition Centers

Quality and customer satisfaction are important agenda for company survival and these two elements are receiving worldwide attention. Service survival and these two elements are receiving worldwide attention. Service industries have begun to recognize that failure to meet quality requirement can have serious consequence that may affect their market share. This study aims to measure the relationship between service quality and customers' satisfaction in tuition center. The survey also aims to gain more insight into the dimension used by the students in evaluating service quality and identify the influencing factors in decision making. To answer the research questions, a research model - which was based on SERVQUAL of performance measurement in service quality, was developed. To test the model, data were collected from the students' satisfaction measures quality system via questionnaire. The stratified systematic sampling was used to select respondents for this study- The finding showed that there is a significant relationship between service quality five dimensions and customers satisfaction. The result also indicated that empathy dimension is the strongest factor that influence the level of customers' satisfaction in tuition centers Besides the theoretical contribution, the research was made useful suggestions in terms of better guideline in order to facilitate target setting, the tracking of the costs of changing quality targets and the linking of pay to quality performance. (Author's abstract

Comparison of amino acids profile and antioxidant activities between edible bird nest and chicken egg

Edible bird’s nest (EBN) and eggs are sources of high quality protein. The objectives of this study were to compare the amino acid profile between EBN and eggs to determine the differences in nutrition composition and antioxidant properties. Amino acid profile and antioxidant properties (DPPH, ABTS and FRAP) of four samples, raw EBN (EBNraw), EBN hydrolysates (EBNh), commercial chicken egg (Eggcomm) and free range chicken egg (EggFR) were determined and correlated with one another. It was found that EBN raw and EBNh have significantly higher (p<0.05) DPPH and ABTS activities compared to Eggcomm and EggFR, whereas Eggcomm and EggFR have significantly higher (p<0.05) FRAP activities compared to EBNraw and EBNh. Amino acid profile analysis showed that Eggcomm and EggFR have significantly higher (p<0.05) methionine, cysteine, lysine and isoleucine content compared to EBNraw and EBNh. Histidine, proline, phenylalanine and tryptophan in EBN were found to have significant (p<0.01) positive correlation with DPPH and ABTS antioxidant activities assays, while methionine and cysteine in chicken eggs have significant (p<0.01) positive correlation with FRAP activity. In conclusion, both EBN and chicken eggs are good sources of proteins and essential amino acids, but EBN showed higher antioxidant activities

Klotho-beta overexpression as a novel target for suppressing proliferation and fibroblast growth factor receptor-4 signaling in hepatocellular carcinoma

<p>Abstract</p> <p>Background</p> <p>We had previously demonstrated overexpression of fibroblast growth factor receptor-4 (FGFR4) in hepatocellular carcinoma (HCC). However, additional molecular mechanisms resulting in amplified FGFR4 signaling in HCC remain under-studied. Here, we studied the mechanistic role of its co-receptor klotho-beta (KLB) in driving elevated FGFR4 activity in HCC progression.</p> <p>Results</p> <p>Quantitative real-time PCR analysis identified frequent elevation of KLB gene expression in HCC tumors relative to matched non-tumor tissue, with a more than two-fold increase correlating with development of multiple tumors in patients. KLB-silencing in Huh7 cells decreased cell proliferation and suppressed FGFR4 downstream signaling. While transient repression of KLB-FGFR4 signaling decreased protein expression of alpha-fetoprotein (AFP), a HCC diagnostic marker, prolonged inhibition enriched for resistant HCC cells exhibiting increased liver stemness.</p> <p>Conclusions</p> <p>Elevated KLB expression in HCC tissues provides further credence to the oncogenic role of increased FGFR4 signaling in HCC progression and represents a novel biomarker to identify additional patients amenable to anti-FGFR4 therapy. The restricted tissue expression profile of KLB, together with the anti-proliferative effect observed with KLB-silencing, also qualifies it as a specific and potent therapeutic target for HCC patients. The enrichment of a liver stem cell-like population in response to extended KLB-FGFR4 repression necessitates further investigation to target the development of drug resistance.</p

Riverine sustainment 2012

Student Integrated ProjectIncludes supplementary materialThis technical report analyzed the Navy's proposed Riverine Force (RF) structure and capabilities for 2012. The Riverine Sustainment 2012 Team (RST) examined the cost and performance of systems of systems which increased RF sustainment in logistically barren environments. RF sustainment was decomposed into its functional areas of supply, repair, and force protection. The functional and physical architectures were developed in parallel and were used to construct an operational architecture for the RF. The RST used mathematical, agent-based and queuing models to analyze various supply, repair and force protection system alternatives. Extraction of modeling data revealed several key insights. Waterborne heavy lift connectors such as the LCU-2000 are vital in the re-supply of the RF when it is operating up river in a non-permissive environment. Airborne heavy lift connectors such as the MV-22 were ineffective and dominated by the waterborne variants in the same environment. Increase in manpower and facilities did appreciable add to the operational availability of the RF. Mean supply response time was the biggest factor effecting operational availability and should be kept below 24 hours to maintain operational availability rates above 80%. Current mortar defenses proposed by the RF are insufficient.N

DDX3X loss is an adverse prognostic marker in diffuse large B-cell lymphoma and is associated with chemoresistance in aggressive non-Hodgkin lymphoma subtypes.

Funder: addenbrooke's charitable trust, cambridge university hospital

Recurrent Fusion Genes in Gastric Cancer: CLDN18-ARHGAP26 Induces Loss of Epithelial Integrity.

Genome rearrangements, a hallmark of cancer, can result in gene fusions with oncogenic properties. Using DNA paired-end-tag (DNA-PET) whole-genome sequencing, we analyzed 15 gastric cancers (GCs) from Southeast Asians. Rearrangements were enriched in open chromatin and shaped by chromatin structure. We identified seven rearrangement hot spots and 136 gene fusions. In three out of 100 GC cases, we found recurrent fusions between CLDN18, a tight junction gene, and ARHGAP26, a gene encoding a RHOA inhibitor. Epithelial cell lines expressing CLDN18-ARHGAP26 displayed a dramatic loss of epithelial phenotype and long protrusions indicative of epithelial-mesenchymal transition (EMT). Fusion-positive cell lines showed impaired barrier properties, reduced cell-cell and cell-extracellular matrix adhesion, retarded wound healing, and inhibition of RHOA. Gain of invasion was seen in cancer cell lines expressing the fusion. Thus, CLDN18-ARHGAP26 mediates epithelial disintegration, possibly leading to stomach H(+) leakage, and the fusion might contribute to invasiveness once a cell is transformed. Cell Rep 2015 Jul 14; 12(2):272-285

COVID-19, Suffering and Palliative Care: A Review

According to the WHO guideline, palliative care is an integral component of COVID-19 management. The relief of physical symptoms and the provision of psychosocial support should be practiced by all healthcare workers caring for COVID-19 patients. In this review, we aim to provide a simple outline on COVID-19, suffering in COVID-19, and the role of palliative care in COVID-19. We also introduce 3 principles of palliative care that can serve as a guide for all healthcare workers caring for COVID-19 patients, which are (1) good symptom control, (2) open and sensitive communication, and (3) caring for the whole team. The pandemic has brought immense suffering, fear and death to people everywhere. The knowledge, skills and experiences from palliative care could be used to relieve the suffering of COVID-19 patients

Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis

BACKGROUND: Rates of antimicrobial resistance (AMR) are rising globally and there is concern that increased migration is contributing to the burden of antibiotic resistance in Europe. However, the effect of migration on the burden of AMR in Europe has not yet been comprehensively examined. Therefore, we did a systematic review and meta-analysis to identify and synthesise data for AMR carriage or infection in migrants to Europe to examine differences in patterns of AMR across migrant groups and in different settings. METHODS: For this systematic review and meta-analysis, we searched MEDLINE, Embase, PubMed, and Scopus with no language restrictions from Jan 1, 2000, to Jan 18, 2017, for primary data from observational studies reporting antibacterial resistance in common bacterial pathogens among migrants to 21 European Union-15 and European Economic Area countries. To be eligible for inclusion, studies had to report data on carriage or infection with laboratory-confirmed antibiotic-resistant organisms in migrant populations. We extracted data from eligible studies and assessed quality using piloted, standardised forms. We did not examine drug resistance in tuberculosis and excluded articles solely reporting on this parameter. We also excluded articles in which migrant status was determined by ethnicity, country of birth of participants' parents, or was not defined, and articles in which data were not disaggregated by migrant status. Outcomes were carriage of or infection with antibiotic-resistant organisms. We used random-effects models to calculate the pooled prevalence of each outcome. The study protocol is registered with PROSPERO, number CRD42016043681. FINDINGS: We identified 2274 articles, of which 23 observational studies reporting on antibiotic resistance in 2319 migrants were included. The pooled prevalence of any AMR carriage or AMR infection in migrants was 25·4% (95% CI 19·1-31·8; I2 =98%), including meticillin-resistant Staphylococcus aureus (7·8%, 4·8-10·7; I2 =92%) and antibiotic-resistant Gram-negative bacteria (27·2%, 17·6-36·8; I2 =94%). The pooled prevalence of any AMR carriage or infection was higher in refugees and asylum seekers (33·0%, 18·3-47·6; I2 =98%) than in other migrant groups (6·6%, 1·8-11·3; I2 =92%). The pooled prevalence of antibiotic-resistant organisms was slightly higher in high-migrant community settings (33·1%, 11·1-55·1; I2 =96%) than in migrants in hospitals (24·3%, 16·1-32·6; I2 =98%). We did not find evidence of high rates of transmission of AMR from migrant to host populations. INTERPRETATION: Migrants are exposed to conditions favouring the emergence of drug resistance during transit and in host countries in Europe. Increased antibiotic resistance among refugees and asylum seekers and in high-migrant community settings (such as refugee camps and detention facilities) highlights the need for improved living conditions, access to health care, and initiatives to facilitate detection of and appropriate high-quality treatment for antibiotic-resistant infections during transit and in host countries. Protocols for the prevention and control of infection and for antibiotic surveillance need to be integrated in all aspects of health care, which should be accessible for all migrant groups, and should target determinants of AMR before, during, and after migration. FUNDING: UK National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare Charity, the Wellcome Trust, and UK National Institute for Health Research Health Protection Research Unit in Healthcare-associated Infections and Antimictobial Resistance at Imperial College London